GaitLab - Rodents locomotions analysis based on the CatWalk Method

GaitLab - based on the CatWalk Method

GaitLab is an automated quantitative gait analysis system for rodents, based on the CatWalk Method. The GaitLab turnkey system allows the evaluation of many locomotor defects, such as those occurring in Parkinson's disease, arthrosis or spinal cord injury.Different endpoints can be assessed depending on your field of interest (animal speed, footprint area, paw area, mean intensity, the number of contact areas...)

Parameters extracted fomr our Gaitlab software:

- “Stride frequency” (s)
- “Stride length” (cm)
- “Stance time” (s)
This parameter refers to the time the animal places a paw on soil.
- “Swing time” (s)
This parameter refers to the time the animal does not place a paw on the soil.
- “Duty factor”
This item refers to the frequency/total time ratio, where “frequency” is the time that the animal uses one of its paws.
- “Fore Lag”
This parameter refers to the lag between the two forelimbs.
- “Hind Lag”
This parameter refers to the lag between the two hindlimbs.
- “Pair Lag” (Abs)
This parameter refers to the lag between the hindlimb and forelimb on a same side.
- “Fore Gap”
This parameter refers to the gap measured between the two forelimbs.
- “Hind Gap”
This parameter refers to the gap measured between the two hindlimbs.
- “Pair Gap” (Abs)
This parameter refers to the gap measured between a hindlimb and a forelimb on a same side.
- “Paw Area” (cm2: length in cm*width in cm)
- “Maximum intensity” (grey level)
Figure 15: Parameters assessed by the GaitLab device
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The intensity refers to the pressure that the animal applies on its paw when it walks.
- “Mean intensity”
- “Intensity sum”
- “Width” (cm) of the paw
- “Length” (cm) of the paw
- “Number of distinct areas” for each paw
- “Forelimbs Base of Support” (cm)
This parameter refers to the interval between two paw prints concerning the forelimbs.
- “Hindlimbs Base of Support” (cm)
This parameter refers to the interval between two paw prints concerning the hindlimbs.
Dynamic parameters
- “Paw area”
- “Max intensity”
- “Mean intensity”
- “Intensity Sum”
- “Number of distinct surface”