VigiePrimates

PUBLICATIONS

An mGlu4‐Positive Allosteric Modulator Alleviates Parkin...

An mGlu4‐Positive Allosteric Modulator Alleviates Parkinsonism in Primates

2018-09-14

Use of adeno-associated virus-mediated delivery of mutan...

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that typically presentsbetween the ages of 35 and 50, with a range of clinical manifestations including motor, cognitive and psychiatric impairments

2020-10-23

Anatomo‐Functional Mapping of the Primate Mesencephalic...

Anatomo‐Functional Mapping of the Primate Mesencephalic Locomotor Region Using Stereotactic Lesions

2019-12-27

Evidence for the spread of human-derived mutant huntingt...

Injection of HD patient-derived homogenates leads to propagation of mHTT in WT mice but does not induce behavioural changes. Injection of HD patient-derived homogenates exacerbates cognitive deficits in BACHD mice and induces localized aggregation. Injection of HD patient-derived homogenates does not change behaviour of Macaques despite long-term presence of aggregates. Injection of HD patient-derived homogenates does not change endogenous HTT in any of the tested conditions.

2020-05-18

Sleep Disorders in Parkinsonian Macaques: Effects of L-D...

Patients with Parkinson's disease (PD) display significant sleep disturbances and daytime sleepiness. Dopaminergic treatment dramatically improves PD motor symptoms, but its action on sleep remains controversial, suggesting a causal role of nondopaminergic lesions in these symptoms.

2014-07-02