Anatomo‐Functional Mapping of the Primate Mesencephalic Locomotor Region Using Stereotactic Lesions

Abstract

Background

Dysfunction of the mesencephalic locomotor region has been implicated in gait disorders. However, the role of its 2 components, the pedunculopontine and the cuneiform nuclei, in locomotion is poorly understood in primates.

Objectives

To analyze the effect of cuneiform lesions on gait and balance in 2 monkeys and to compare them with those obtained after cholinergic pedunculopontine lesions in 4 monkeys and after lesions in both the cuneiform and pedunculopontine nuclei in 1 monkey.

 

Link to the publication : 

https://movementdisorders.onlinelibrary.wiley.com/doi/abs/10.1002/mds.27983