Developmental neurotoxicity fingerprint of silica nanoparticles at environmentally relevant level on larval zebrafish using a neurobehavioral-phenomics-based biological warning method

Highlights

 

• Silica NPs at environmental level induced the negligible embryonic teratogenicity.
• Silica NPs at environmental level altered behavioral profiles determined by NBP.
• NBP are more sensitive and effective than FET to determine sub-teratogenic toxicity.

Abstract

Background

Larval zebrafish (Danio rerio) is not only an ideal vertebrate applied in Fish Embryos Toxicity (FET) test but also a well-accepted model in behavioral neurotoxicity research. By applying the commercial standard behavioral tracking system (Zebrabox), the locomotion profiles (neurobehavioral-phenomics) of larval zebrafish can be comprehensively monitored and systematically analyzed to probe ecotoxicological neurotoxicity of nano-pollutants at environmental relevant concentration level.

 

Link to the publication : 

https://www.sciencedirect.com/science/article/abs/pii/S0048969720354073