Experience of behavior on mice
Ciproxifan 3 mg/kg has an enhancing effect on working memory (WM) after an acute sleep restriction, via a decrease of proactive interference sensitivity. The cognitive beneficial effect of ciproxifan in sleep-restricted mice is associated to specific prefrontal cortex area activation.
Patients with Parkinson's disease (PD) display significant sleep disturbances and daytime sleepiness. Dopaminergic treatment dramatically improves PD motor symptoms, but its action on sleep remains controversial, suggesting a causal role of nondopaminergic lesions in these symptoms.