ZebraLab

PUBLICATIONS

The mineralocorticoid receptor is essential for stress a...

The mineralocorticoid receptor is essential for stress axis regulation in zebrafish larvae

2018-12-27

Ecotoxicological effects, water quality standards and ri...

Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin

2018-09-08

Swimming activity in zebrafish larvae exposed to veterin...

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals

2018-08-25

A novel metabolism-based phenotypic drug discovery platf...

A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target

2018-01-24

Behavioural responses in effect to chemical stress in fi...

Behavioural responses in effect to chemical stress in fish

2018-12-03

Embryotoxicity of ozonated diclofenac, carbamazepine, an...

Pharmaceutical residues are polluting the surface water environments worldwide. Sewage and wastewater treatment, therefore, needs to be improved in order to remove pharmaceutical residues from the effluent. One such treatment improvement is effluent ozonation. Even though ozonation has proven to be very efficient in reducing pharmaceutical parent compound concentrations in wastewater effluents, much remains unclear regarding potentially toxic ozonation by-product (OBP) formation. In this study, we sought to elucidate the aquatic toxicity of ozonated pharmaceuticals in zebrafish (Danio rerio) embryos in a static 144 h post fertilization (hpf) fish embryotoxicity (ZFET) assay. Three pharmaceuticals commonly detected in wastewater effluents, i.e. carbamazepine, diclofenac, and oxazepam, were selected for testing. Toxicity was assessed before and after 1 min ozonation (0.053 mg L-1 peak O3 concentration) and 10 min ozonation (0.147 mg L-1 peak O3 concentration). Chemical analysis showed that carbamazepine and diclofenac were largely removed by ozone (90±11% and 97±3.8%), whereas oxazepam was removed to a lesser extent (19±5.7%). The ZFET assay revealed diverging toxicities. Diclofenac embryotoxicity decreased with increasing ozonation. Oxazepam did not cause embryotoxicity in the ZFET assay either pre- or post ozonation, but larvae swimming activity was affected at 144 hpf. Carbamazepine embryotoxicity, on the other hand, increased with increasing ozonation. Chemical analysis showed the formation of two OBPs (carbamazepine-10,11- epoxide and 10,11-dihydrocarbamazepine), possibly explaining the increased embryotoxicity. The results of this study highlight the importance of new chemical and toxicological knowledge regarding the formation of OBPs in post-ozonated effluents.

2019-03-06

Identifcation of pathways that regulate circadian rhythm...

Identifcation of pathways that regulate circadian rhythms using a larval zebrafsh small molecule screen

2014-01-01

Zebrafish neurobehavioral phenomics applied as the behav...

Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level

2019-05-20

Long‑term acclimation to near‑future ocean acidifcation...

Long‑term acclimation to near‑future ocean acidifcation has negligible efects on energetic attributes in a juvenile coral reef fsh

2019-06-04

Enantioselectivity of toxicological responses induced by...

The maternal transfer and developmental toxicity of chiral contaminants with respect to enantioselectivity have rarely been investigated. Here, the residues and toxicological responses of cis-BF, a typical chiral pesticide, were studied in the progeny of adult zebrafish exposed to cis-BF (0, 20, 100, and 500 ng/L) for 60 days. Cis-BF enantiomers exhibited the equal maternal transfer potentials. GC/MSD analysis showed that parental 1S-cis-BF exposure could disrupt the components of fatty acids in offspring embryos. In transcriptional expression, the whole differentially expressed genes were significantly enriched in GO categories, including the processes related to lipid biosynthesis/metabolism. The perturbations of fatty acids suggested that cis-BF has potential negative impacts on embryos’ development. Furthermore, enantioselective growth inhibition and developmental neurotoxicity in larvae were also observed. The mRNA expressions of neuronal development genes were significantly changed in 1S-exposed offspring, so were the levels of the neurotransmitters and larval locomotion. Our results show that the cis-BF induced the growth inhibition and neurotoxicity in zebrafish larvae, which may be mediated by the development interference in embryos related to the disrupted fatty acid composition. Furthermore, the toxicological response to 1S-cis-BF was greater than that to the 1R-enantiomer in the offspring of exposed adults.

2019-03-01

Novel Kunitz-like peptides discovered in the zoanthid Pa...

http://pubs.acs.org/doi/abs/10.1021/acs.jproteome.7b00686

2017-12-29

Nonlinear mixed-modelling discriminates the effect of ch...

Nonlinear mixed-modelling discriminates the effect of chemicals and their mixtures on zebrafish behavior

2018-01-12

High-performance counter-current chromatography isolatio...

High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L (Apiaceae)

2018-10-26

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NCBINCBI Logo Skip to main content Skip to navigation Resources How To About NCBI Accesskeys Sign in to NCBI PubMed US National Library of Medicine National Institutes of Health Search database Search term Clear input Advanced Help Result Filters Format: Abstract Send to Chemosphere. 2018 Jan 25;197:611-621. doi: 10.1016/j.chemosphere.2018.01.092. [Epub ahead of print] Developmental toxicity induced by PM2.5 through endoplasmic reticulum stress and autophagy pathway in zebrafish embryos.

2018-02-01

Evaluation of neuroactive effects of ethanol extract of...

Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling

2018-12-27

A zebrafish model to study small-fiber neuropathy reveal...

A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1

2019-01-22

Effects of 17α‑ethinylestradiol on caudal fin regenerati...

Effects of 17α‑ethinylestradiol on caudal fin regeneration in zebrafish larvae

2018-10-21

Sub-lethal UV radiation during early life stages alters...

Sub-lethal UV radiation during early life stages alters the behaviour, heart rate and oxidative stress parameters in zebrafish (Danio rerio)

2018-10-01

Ezh2 promotes clock function and hematopoiesis independe...

https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gky101/4852815

2018-02-13

Neurobehavioral effects of two metabolites of BDE-47 (6-...

https://www.sciencedirect.com/science/article/pii/S0045653518302662

2013-01-01

Effects of UV filter 4-methylbenzylidene camphor during...

https://www.sciencedirect.com/science/article/pii/S0048969718305023

2018-02-20

Using Zebrafish for Investigating the Molecular Mechanis...

Using Zebrafish for Investigating the Molecular Mechanisms of Drug-Induced Cardiotoxicity

2018-09-27

A Zebrafish Behavior Assay for Assessing Anti- Epileptic...

A Zebrafish Behavior Assay for Assessing Anti- Epileptic Drug Efficacy

2018-10-17

Drug repositioning in epilepsy reveals novel antiseizure...

Drug repositioning in epilepsy reveals novel antiseizure candidates

2018-10-26

Normalization of large-scale behavioural data collected...

Normalization of large-scale behavioural data collected from zebrafish

2019-02-15

Embryonic development, locomotor behavior, biochemical,...

Embryonic development, locomotor behavior, biochemical, and epigenetic effects of the pharmaceutical drugs paracetamol and ciprofloxacin in larvae and embryos of Danio rerio when exposed to environmental realistic levels of both drugs

2019-01-19

Protecting the environment from psychoactive drugs: Prob...

Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour

2014-01-01

Automated, high-throughput, in vivo analysis of visual f...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844763/

2016-03-06

Mitigating Human IAPP Amyloidogenesis In Vivo with Chira...

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

2013-01-01

Subunits of the mechano-electrical transduction channel,...

Subunits of the mechano-electrical transduction channel, Tmc1/2b, require Tmie to localize in zebrafish sensory hair cells

2019-02-06

Zebrafish Behavioral Profiling Links Drugs to Biological...

We report the development and application of a high-throughput, quantitative screen for drugs that alter the behavior of larval zebrafish. We found that the multidimensional nature of observed phenotypes enabled the hierarchical clustering of molecules according to shared behaviors.

2013-01-15

Automated morphological feature assessment for zebrafish...

Automated morphological feature assessment for zebrafish embryo developmental toxicity screens

2018-10-01

Development of a high-throughput in vivo screening platf...

https://www.sciencedirect.com/science/article/pii/S0269749117344469

2018-02-21

Sleep deprivation caused a memory defects and emotional...

Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson’s disease

2019-06-10

Using Touch-evoked Response and Locomotion Assays to Ass...

Using Touch-evoked Response and Locomotion Assays to Assess Muscle Performance and Function in Zebrafish

2016-10-31

Role of Olfactorily Responsive Neurons in the Right Dors...

Role of Olfactorily Responsive Neurons in the Right Dorsal Habenula - Ventral Interpeduncular Nucleus Pathway in Food- Seeking Behaviors of Larval Zebrafish

2019-02-05

Toxicity and neurotoxicity profiling of contaminated sed...

Toxicity and neurotoxicity profiling of contaminated sediments from Gulf of Bothnia (Sweden): a multi-endpoint assay with Zebrafish embryos

2019-02-04

Multigenerational consequences of early-life cannabinoid...

Multigenerational consequences of early-life cannabinoid exposure in zebrafish

2018-12-26

Synergistic effects of Pb and repeated heat pulse on dev...

Synergistic effects of Pb and repeated heat pulse on developmental neurotoxicity in zebrafish

2019-02-06

Developmental protein kinase C hyper-activation results...

Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish

2018-10-23

2,4-Dichlorophenoxyacetic acid herbicide effects on zebr...

2,4-Dichlorophenoxyacetic acid herbicide effects on zebrafish larvae: development, neurotransmission and behavior as sensitive endpoints

2019-02-05

Novel neurotoxic peptides from Protopalythoa variabilis...

Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish

2018-10-17

Biallelic VARS variants cause developmental encephalopat...

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

2019-02-12

Identification of GSK-3 as a Potential Therapeutic Entry...

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy

2018-10-23

Varying the exposure period and duration of neuroactive...

Varying the exposure period and duration of neuroactive pharmaceuticals and their metabolites modulates effects on the visual motor response in zebrafish (Danio rerio) larvae

2019-01-31

Lethal and sub-lethal effects of cyproconazole on freshw...

https://link.springer.com/article/10.1007/s11356-017-1180-y

2018-02-18

Knockdown of chondroitin-4-sulfotransferase-1, but not o...

Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury

2018-10-19

Evaluation of neuroactive effects of ethanol extract of...

Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling

2018-12-27

Hormetic effect of panaxatriol saponins confers neuropro...

Zhang, C. et al. Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways. Sci. Rep. 7, 41082; doi: 10.1038/srep41082 (2017).

2017-01-23

Maternal cortisol stimulates neurogenesis and affects la...

Best, C. et al. Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Sci. Rep. 7, 40905; doi: 10.1038/srep40905 (2017).

2017-01-18

A New Statistical Approach to Characterize Chemical-Elic...

Zhang G, Truong L, Tanguay RL, Reif DM (2017) A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish. PLoS ONE 12(1): e0169408. doi:10.1371/journal.pone.0169408

2017-01-18

Expression of pathogenic SCN9A mutations in the zebrafis...

Expression of pathogenic SCN9A mutations in the zebrafish: A model to study small fiber neuropathy

2018-10-11

Effects of titanium dioxide nanoparticles exposure on pa...

http://www.sciencedirect.com/science/article/pii/S0045653517300735

2017-01-21

Motor Neuron Abnormalities Correlate with Impaired Movem...

Motor Neuron Abnormalities Correlate with Impaired Movement in Zebrafish that Express Mutant Superoxide Dismutase 1

2018-10-09

A novel method for automated tracking and quantification...

Highlights Custom-made economic imaging setup for distraction-free behavioural recording. ImageJ based algorithm for fast and automated tracking of Zebrafish without plugins. Mathematical workflow for extraction of behavioural endpoints. New representation for spatio-temporal nature of choice-based behaviours.

2011-01-01

Reversal of pentylenetetrazole-altered swimming and neur...

Extensive ethnopharmaceutical documentation is available on plants with demonstrated psychoactivity in humans (for review (Raetsch 2005)). Even though there is a huge need for new molecules in mental health, this reservoir of knowledge remains greatly untapped. One of the main reasons is probably the lack of a good in vivo system allowing testing of psychoactive efficacy of complex mixtures of unknown composition. Ethnobotanical reports on a specific plant often differ on plant species/subspecies/harvest but also on mode of preparation and administration which all generate a number of imponderable parameters. Therefore, it is necessary to establish a system which would be capable of circumventing those problems. Ideally, the proposed system has to be flexible and sensitive enough to allow rapid and systematic screening of a big number of complex mixtures like crude plants extracts. In such a system, first pass screening could be done with minimally processed extracts like preparations made from dried powdered parts of a plant of interest. Subsequently, gradually refined mixtures could be tested the same way to eventually isolate the active compound(s).

2011-01-01

The role of humic acids on gemfibrozil toxicity to zebra...

The role of humic acids on gemfibrozil toxicity to zebrafish embryos

2018-12-19

RGD inhibition of itgb1 ameliorates laminin-a2 deficient...

RGD inhibition of itgb1 ameliorates laminin-a2 deficient zebrafish fibre pathology

2018-12-19

Advancing the zebrafish embryo test for endocrine disrup...

Advancing the zebrafish embryo test for endocrine disruptor screening using micro‐injection: ethinyl estradiol as a case study

2014-01-01

Bioassay-guided isolation of anti-seizure principles fro...

Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model

2018-12-17

Developmental neurotoxicity and immunotoxicity induced b...

Developmental neurotoxicity and immunotoxicity induced by graphene oxide in zebrafish embryos

2018-12-13

TBBPA exposure during a sensitive developmental window p...

8–48 hpf is the sensitive exposure window for neurodevelopmental and behavioral toxicities of TBBPA. TBBPA induced apoptotic cell death and affected motor neuron and muscle fiber development. Zebrafish embryos rapidly absorbed and accumulated TBBPA, and eliminated it quickly. • TBBPA induced ugt genes expression, which increased T4 metabolism and subsequently induced neurobehavior defects.

2016-07-01

TBBPA chronic exposure produces sex-specific neurobehavi...

Low dose TBBPA chronic exposure reduced zebrafish body weight and length. TBBPA exposure induced adult zebrafish hyperactivity with magnitude bigger in males than in females. Low dose TBBPA exposure induced male zebrafish heightened aggression using mirror attack test.

2016-07-01

Lethal dysregulation of energy metabolism during embryon...

http://www.sciencedirect.com/science/article/pii/S0891584917300291

2017-01-21

Vitamin E reduces endosulfan-induced toxic effects on mo...

http://www.sciencedirect.com/science/article/pii/S0278691517300042

2017-01-10

Testing of therapies in a novel nebulin nemaline myopath...

https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0546-9

2018-05-30

Perfluorododecanoic acid exposure induced developmental...

https://www.sciencedirect.com/science/article/pii/S0269749117352247

2018-06-08

High-throughput Screening in Larval Zebrafish Identifies...

http://anesthesiology.pubs.asahq.org/article.aspx?articleid=2685007

2018-06-11

Influence of pH on the uptake and toxicity of β-blockers...

https://www.sciencedirect.com/science/article/pii/S0166445X18301152

2018-05-28

Phenelzine, a cell adhesion molecule L1 mimetic small or...

https://www.sciencedirect.com/science/article/pii/S0091305717307062

2018-05-24

Use of Gammarus fossarum (Amphipoda) embryo for toxicity...

http://onlinelibrary.wiley.com/doi/10.1002/etc.3779/full

2017-03-07

Effects of effluent wastewater in developing zebrafish (...

http://uu.diva-portal.org/smash/get/diva2:1197925/FULLTEXT01.pdf

2018-05-22

Behavioral Profiling of Zebrafish (Danio rerio) Larvae F...

https://link.springer.com/protocol/10.1007/978-1-4939-7883-0_22

2018-06-13

Comparative behavioral toxicology with two common larval...

https://www.sciencedirect.com/science/article/pii/S004896971832059X

2018-06-18

Biodegradable Si3N4 bioceramic sintered with Sr, Mg and...

https://www.sciencedirect.com/science/article/pii/S2352940718302099

2018-07-27

Linking genomic responses of gonads with reproductive im...

http://www.sciencedirect.com/science/article/pii/S0166445X16303794

2017-01-03

The Locus Coeruleus Modulates Intravenous General Anesth...

The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism

2018-09-01

Influence of diltiazem on fathead minnows across dissolv...

https://setac.onlinelibrary.wiley.com/doi/abs/10.1002/etc.4242

2018-07-28

Auriculasin from Flemingia philippinensis roots shows go...

https://www.sciencedirect.com/science/article/pii/S0006291X18315286

2018-07-17

Biodegradable Si3N4 bioceramic sintered with Sr, Mg and...

https://www.sciencedirect.com/science/article/pii/S2352940718302099

2018-06-27

Chromosome-level reference genome of the Siamese fightin...

https://doi.org/10.1093/gigascience/giy087

2018-07-11

A Small Organic Compound Mimicking the L1 Cell Adhesion...

http://link.springer.com/article/10.1007/s12035-016-0254-z

2017-01-14

Eriocaulon buergerianum extract protects PC12 cells and...

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

2011-06-06

Impact of co-exposure to titanium dioxide nanoparticles...

Impact of co-exposure to titanium dioxide nanoparticles and Pb on zebrafish embryos

2019-06-03

Neurodevelopmental toxicity assessments of alkyl phenant...

Neurodevelopmental toxicity assessments of alkyl phenanthrene and Dechlorane Plus co-exposure in zebrafish

2019-05-30

A long noncoding RNA cluster-based genomic locus maintai...

A long noncoding RNA cluster-based genomic locus maintains proper development and visual function

2019-05-10

Zebrafish as a new model for phenotype-based screening o...

The zebrafish-based assay is a widely used animal model system for cardiovascular research. In this study, we investigated the cardiac defects caused by terfenadine and tested the pharmacological response of digoxin to zebrafish with cardiac defects.

2014-07-04

NEUROPROTECTIVE COMPOSITION , PREPARATION PROCESS THEREO...

NEUROPROTECTIVE COMPOSITION , PREPARATION PROCESS THEREOF AND MEDICAL USES THEREOF

2014-01-01

Discovery of a Natural Product-Like iNOS Inhibitor by Mo...

In this study, we applied structure-based virtual screening techniques to identify natural product or natural product-like inhibitors of iNOS.

2014-04-01

Applicability of the TCDD-TEQ approach to predict sublet...

Ecotoxicology with the ZebraBox

2014-02-18

Combined transcriptomic and proteomic analysis reveals a...

Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia)

2019-06-15

Neural signatures of sleep in zebrafish

Neural signatures of sleep in zebrafish

2014-01-01

Life history and behavior effects of synthetic and natur...

Life history and behavior effects of synthetic and natural dyes on Daphnia magna

2019-04-18

Behavioral effects of citalopram, tramadol, and binary m...

Behavioral effects of citalopram, tramadol, and binary mixture in zebrafish (Danio rerio) larvae

2019-08-13

Coexposure to environmental concentrations of cis-bifent...

Coexposure to environmental concentrations of cis-bifenthrin and graphene oxide: Adverse effects on the nervous system during metamorphic development of Xenopus laevis

2019-08-12

Involvement of peroxisome proliferator-activated recepto...

Involvement of peroxisome proliferator-activated receptor γ in anticonvulsant activity of α-asaronol against pentylenetetrazole-induced seizures in zebrafish

2019-09-02

Inherited and De Novo Genetic Risk for Autism Impacts Sh...

Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks

2019-08-08

Effects of antidepressants with different modes of actio...

Effects of antidepressants with different modes of action on early life stages of fish and amphibians

2019-08-06

Ferredoxin 1b deficiency leads to testis disorganization...

Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish

2019-01-19

Toxicity assessment of zebrafish following exposure...

Toxicity assessment of zebrafish following exposure to CdTe QDs

2012-02-14

Antinociceptive effects of buprenorphine in zebrafish la...

The underlying processes of nociception and pain are, despite the rodent models available, still not fully understood. One of the drawbacks of rodent model systems is the difficulty to screen compound libraries for their influence on nociception, thus slowing down the discovery of novel analgesics for clinical use.

2014-03-10

Optical toxicity of triphenyl phosphate in zebrafish lar...

Triphenyl phosphate (TPhP) has been shown to cause developmental neurotoxicty. Considering the visual system is a sensitive target, in the present study, we investigated the potential toxicity of TPhP on the visual development and function ACCEPTED MANUSCRIPT 2 in zebrafish larvae. Embryos were exposed to 0, 0.1, 1, 10, and 30 μg/L TPhP from 2 to 144 hours post-fertilization (hpf). The transcription of photoreceptor opsin genes, and histopathological changes in the retina and visual behavior (optokinetic and phototactic responses) were evaluated. TPhP significantly downregulated the transcription of opsin genes (zfrho, opn1sw1, opn1sw2, opn1mw1, opn1mw2, opn1mw3, opn1mw4, opn1lw1 and opn1lw2) in all exposure groups. Histopathological analysis revealed that the areas of the outer nuclear layer (ONL), inner nuclear layer (INL), and inner plexiform layer (IPL) of the retina were significantly reduced in the 10 and 30 μg/L TPhP groups. The number of ganglion cells was reduced significantly in the 30 μg/L group. The optokinetic response (OKR) and phototactic response showed dose-dependent decreases caused by impaired visual function, which was confirmed by unchanged locomotor activity. The results indicated that exposure to environmentally relevant concentrations of TPhP could inhibit the transcription of genes related to visual function and impair retinal development, thus leading to visual impairment in zebrafish larvae.

2014-01-01

Long-term effects of oxytetracycline exposure in zebrafi...

Long-term effects of oxytetracycline exposure in zebrafish: A multi-level perspective

2014-01-01

Knockdown of Type 3 Iodothyronine Deiodinase Severely Pe...

Zebrafish care The Wild Indian Karyotype (WIK) strain of zebrafish was reared in community tanks on a 14-hour light, 10-hour dark cycle. Fish were fed twice a day, once with formulated feed (Dr. Bassleer Biofish Food) and once with Artemia larvae (cysts from Ocean Nutrition Europe). Eggs were collected 20 minutes after natural spawning and rinsed with system water to minimize infections. Embryos were raised at 28 ± 0.5°C in Danieau's medium. All animal experiments were approved by the Institutional Ethical Committee of the Katholieke Universiteit Leuven and executed in strict accordance with the European Council Directive (2010/63/EC).

2014-01-27

Expression and functions of ASIC1 in the zebrafish retin...

Highlights • Both asic1 mRNA and protein expressions were detected in the adult zebrafish retina. • Acidosis-induced currents in the isolated retinal ganglion cells (RGCs) were recorded using whole cell patch clamping. • Blockade of ASICs channel significantly reduced the locomotion of larval zebrafish in response to light exposure.

2014-12-01

A high-throughput zebrafish screening method for visual...

Normal and visually-impaired zebrafish larvae have differentiable light-induced locomotor response (LLR), which is composed of visual and non-visual components

2014-08-09

Behavioural responses in effect to chemical stress in fi...

Behavioural responses in effect to chemical stress in fish: A review

2019-01-05

Use of the Zebrafish Larvae as a Model to Study Cigarett...

The link between tobacco use and the development of serious diseases such as certain cancers, heart disease, respiratory diseases and stroke are well established [1]. Despite this, tobacco use continues to be a growing global epidemic and remains the leading cause of preventable death worldwide [2]. More than 37,000 Canadians have been estimated to die prematurely on an annual basis as a consequence of tobacco smoking [3] and costs to the health care system are estimated at over $4.3 billion annually [4]. As such, tobacco use remains a public health concern in Canada.

2014-12-18

Identification of compounds with anti-convulsant propert...

The availability of animal models of epileptic seizures provides opportunities to identify novel anticonvulsants for the treatment of people with epilepsy.

2012-11-01

Abnormal differentiation of dopaminergic neurons in zebr...

Highlights • Zebrafish trpm7 mutant larvae exhibit dopamine-responsive behavioral deficits. • In such larvae, dopaminergic neurons express DAT but many lack expression of TH. • trpm7 mutant larvae are hyper-sensitive to a toxin of dopaminergic neurons, MPP+. • We show that SH-SY5Y cells, which are dopaminergic, depend on TRPM7 for survival. • How Trpm7 contributes to function and viability of dopaminergic neurons is unknown.

2010-01-01

Measuring changes in locomotor activity of freshwater pr...

As the population grows, so does the drive for urbanization. Urbanization and the resulting anthropogenic activities have an impact on the quality of nearby water resources. Puerto Rico’s population density is one of the highest in the world. We seek to develop a protocol to measure how Puerto Rico´s high level of urban development has impacted the behavior and nervous system function of river fauna. We have started by recording movement trajectory and velocity of freshwater prawn larvae during five consecutive periods of 10-minutes light/dark cycles, using ViewPoint´s Zebrabox.

2014-04-01

Zebrafish embryotoxicity test for developmental (neuro)t...

Highlights • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET.

2015-04-01

Quantitative Cross-Species Extrapolation between Humans...

Fish are an important model for the pharmacological and toxicological characterization of human pharmaceuticals in drug discovery, drug safety assessment and environmental toxicology. However, do fish respond to pharmaceuticals as humans do? To address this question, we provide a novel quantitative cross-species extrapolation approach (qCSE) ...

2014-10-22

Hippocampal Memory Traces Are Differentially Modulated b...

Memory traces are believed to be ensembles of cells used to store memories. To visualize memory traces, we created a transgenic line that allows for the comparison between cells activated during encoding and expression of a memory.

2014-07-04

Rest mutant zebrafish swim erratically and display atypi...

Highlights • Adult rest mutants engage in erratic swimming and display atypical spatial preferences. • rest mutant larvae are hypoactive when compared to sibling controls. • Adult rest mutant males but not females show diminished reproductive success.

2015-04-01

Antinociceptive effects of buprenorphine in zebrafish la...

Keywords Buprenorphine; Cyclooxygenase-2; Nociception; Pain; Zebrafish larvae

2014-03-01

Zebrafish embryotoxicity test for developmental (neuro)

HIGHLIGHTS - The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints - Morphology, motor activity, histopathology, kinetics and gene expression were studied - A series of anti-epileptic drugs showed specific sensitivity for each endpoint - This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET - This test strategy may contribute to better define the applicability domain of the ZET

2014-03-15

Linarin improves the dyskinesia recovery in Alzheimer's...

Linarin improves the dyskinesia recovery in Alzheimer's disease zebrafish by inhibiting the acetylcholinesterase activity

2019-02-22

High-throughput behavioral assay to investigate seizure...

https://www.tandfonline.com/doi/abs/10.1080/01677063.2018.1445247

2018-05-02

Modulation of Threat Response in Larval Zebrafish

https://link.springer.com/protocol/10.1007/978-1-4939-7847-2_11

2018-05-08

Analysis of neurobehavioural data by chemometric methods...

http://www.sciencedirect.com/science/article/pii/S0147651317305092

2017-08-09

Effects of copper oxide nanoparticles and copper ions to...

http://www.sciencedirect.com/science/article/pii/S0887233317302266

2017-08-15

The Power of Zebrafish in Personalised Medicine

https://link.springer.com/chapter/10.1007/978-3-319-60733-7_10

2017-08-25

Inhibition of glutamate decarboxylase (GAD) by ethyl ket...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543107/

2017-08-03

Endocrine, teratogenic and neurotoxic effects of cyanoba...

http://www.sciencedirect.com/science/article/pii/S0045653514009370

2017-07-27

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2017-07-07

Performance Study of TiO2-Au Photoelectric Nanocomposite...

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Distinct roles of neuroepithelial-like and radial glia-l...

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Effects of ibuprofen, diclofenac and paracetamol on hatc...

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Vitamin E deficiency during embryogenesis in zebrafish c...

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2017-06-20

Transgenerational endocrine disruption and neurotoxicity...

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Light-Dependent Regulation of Sleep and Wake States by P...

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Physiological role of amyloid precursor protein during n...

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Evaluation of the sensitivity spectrum of a video tracki...

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Graphene Oxide Quantum Dots Reduce Oxidative Stress and...

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Advancement of Passive Sampling Applications for Assessi...

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Cystinosis (ctns) zebrafish mutant shows pronephric glom...

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Functional analysis of the transmembrane and cytoplasmic...

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Depdc5 knockdown causes mTOR-dependent motor hyperactivi...

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2018-02-08

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2017-11-16

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2017-03-07

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2013-12-20

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2009-01-01

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2013-06-01

Drug Screening to Treat Early-Onset Eye Diseases: Can Ze...

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2012-10-23

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2013-06-20

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2010-01-01

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