SIRT1 activation rescues the mislocalization of RNA-binding proteins and cognitive defects induced by inherited cobalamin disorders
Published: 10-28-2019 In Publication
- • Defects of cobalamin metabolism lead to mislocalization of RNA binding proteins.
- • SRT1720 treatment rescued abnormal localization of RNA binding proteins.
- • SRT1720 treatment improved the cognitive defects observed in a transgenic mouse model.