BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS

Published: 04-03-2020 In Publication


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BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS

It is an object of the present invention to provide new therapeutic methods and compositions for treating neurological disorders. More particularly, the invention relates to compositions and methods for treating neurological disorders related to glutamate and/or amyloid beta (Aβ) toxicity, based on a combination of baclofen and acamprosate.

The invention stems, inter alia, from the unexpected discovery, by the inventors, that the combination of baclofen and acamprosate provides substantial and unexpected benefit to patients with Alzheimer's disease. Moreover, the inventors have surprisingly discovered that this combination provides substantial and unexpected protection of neuronal cells against various injuries encountered in neurological disorders including glutamate toxicity. Thus, this combination of baclofen and acamprosate constitutes an efficient treatment for patients suffering from, predisposed to, or suspected to suffer from neurological disorders. The inventors have found that combinations of the invention are efficient in counteracting the toxic cellular effects of Aβ peptides and in correcting the cognitive impairments in relation with such toxicity. The invention further demonstrates that baclofen and acamprosate administration does improve memory functions in aged subjects as well as cognitive functions, in particular by correcting cognition-related electro-physiological features in mild AD patients.

 

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