Zebrafish embryotoxicity test for developmental (neuro)



Behavior recording system, together with the associated movement tracking and analysis software 166 (Zebrabox, ViewPoint, France). ... closed Zebrabox. The larvae were allowed an average of 15 minutes to acclimatize in the Zebrabox.

HIGHLIGHTS - The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints - Morphology, motor activity, histopathology, kinetics and gene expression were studied - A series of anti-epileptic drugs showed specific sensitivity for each endpoint - This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET - This test strategy may contribute to better define the applicability domain of the ZET